关于巴基斯坦艾滋病毒感染者长期注射抗逆转录病毒治疗的可接受性和偏好
Muhammad Wasay Shahid1, Masood-Ur- Rehman1, Faizur Rehman1
1Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.
HIV research & clinical practice
|February 23, 2026
概括
长效注射抗逆转录病毒疗法 (LAI-ART) 对巴基斯坦艾滋病毒感染者来说是可以接受的,提供了更好的坚持和隐私. 成功实施需要解决安全,供应和有效治疗艾滋病毒的获取问题.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 艾滋病毒/艾滋病 治疗
背景情况:
- 长效注射抗逆转录病毒疗法 (LAI-ART) 为艾滋病毒感染者提供了一种新的替代每日口服抗逆转录病毒疗法 (ART).
- LAI-ART有可能提高治疗坚持,减少剂量频率,减轻治疗疲劳.
- 由于潜在的结构和卫生系统障碍,在低收入和中等收入国家,特别是巴基斯坦,LAI-ART的可接受性和可行性存在有限的现实数据.
研究的目的:
- 在巴基斯坦目前接受口服ART的个人中探索LAI-ART的可行性和可接受性的观点.
- 确定潜在的好处和障碍,影响在巴基斯坦背景下采用LAI-ART.
主要方法:
- 在2024年11月至2025年1月期间进行了一项定性研究.
- 数据收集涉及31名艾滋病毒感染者的深入采访和一个聚焦小组讨论 (FGD),其中包括来自巴基斯坦各地社区同行倡导小组的6名参与者.
- 传统的主题分析与感应编码被用于数据分析.
主要成果:
- 参与者对LAI-ART的看法很好,他们认为LAI-ART的好处包括:消除药物负担,改善药物坚持,减少副作用,减少后勤需求,提高隐私.
- 实施LAI-ART的主要障碍包括注射相关的不良事件,延长诊所等待时间和有限的可用性.
- 一些参与者表示不愿意,因为他们对口服ART的信任,多个月的补充的方便性,对坚持的担忧,以及与工作相关的约束.
结论:
- 巴基斯坦艾滋病毒感染者认为LAI-ART是可以接受的,在遵守和隐私方面提供了显著的优势.
- 成功实施取决于主动解决与安全,供应链和可访问性有关的问题.
- 开发响应性,无耻感和以人为中心的护理模式对于优化LAI-ART集成至关重要.
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