针对微生物群-肠-大脑轴:Bacillus coagulans可以保护大鼠免受轮诱导的帕金森病的影响

针对微生物群-肠-大脑轴:Bacillus coagulans可以保护大鼠免受轮诱导的帕金森病的影响

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Monalisa Rout¹, Shakti Ketan Prusty², Vishal Singh²

¹School of Pharmaceutical Sciences-II, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, India.

Neurochemical research

|February 23, 2026

概括

细菌凝血菌的益生菌可能通过调节肠道微生物群-肠道-大脑轴,在帕金森病 (PD) 中提供神经保护. 这项研究表明益生菌有潜力支持PD管理和减缓疾病进展.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
胃肠病学胃肠病学

背景情况:

肠道微生物群功能障碍与帕金森病 (PD) 病原发生有关.
帕金森病涉及α-synuclein聚合,氧化应激,神经炎症和多巴胺基神经元损失.
微生物群-肠-大脑轴 (MGBA) 是一个关键途径,将肠道健康与大脑功能联系起来.

研究的目的:

为了研究Bacillus coagulans (B. coagulans) 的神经保护作用,在帕金森病的罗诺诱导的老鼠模型中.
评估B.凝血素对肠道微生物群组成的影响,以及MGBA在实验性PD中的影响.

主要方法:

雄性大鼠被给予罗 (ROT) 诱导帕金森病样病理.
鼠被用Bacillus coagulans治疗. 鼠被用Bacillus coagulans治疗. 鼠被用Bacillus coagulans治疗. 鼠被用Bacillus coagulans治疗. 鼠被用Bacillus coagulans治疗.
用qPCR分析肠道同质物,以评估微生物组成.
评估了运动缺陷和α-synuclein积累.

主要成果:

轮诱导肠道屏障功能障碍,肠道失调,α-synuclein积累和运动缺陷.
治疗Bacillus coagulans改变了rotenone诱导的PD大鼠的肠道微生物组成.
通过MGBA,B.凝固剂显示出潜在的神经保护作用.

结论:

凝血菌可以作为治疗帕金森病的辅助剂.
益生菌干预可以潜在地恢复肠道健康,并通过MGBA减轻PD进展.

关键词:

B. 凝血剂是一种凝血剂.我们的肠道微生物群.肠-大脑轴肠-大脑轴帕金森病是帕金森氏症的一种疾病.益生菌益生菌益生菌

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