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老龄化和罕见疾病:从流行病学到呼吁采取行动

Monica Mazzucato^1,2, Giulia Fanton³, Andrea Vianello⁴

¹Rare Diseases Coordinating Centre, Padua University Hospital, Veneto Region, Padua, Italy. monica.mazzucato@unipd.it.

European geriatric medicine

|February 23, 2026

概括

老年人是罕见疾病 (RD) 人口中的一个不断增长的部分. 在2022年,超过9500个65岁以上的个人有RDs,突出了需要专门的老年护理.

科学领域:

老年病的医生老年病的医生
罕见疾病流行病学流行病学

背景情况:

全球人口老龄化和医疗保健的改善正在增加患有罕见疾病的老年人数.
由于诊断和治疗的复杂性,罕见疾病在老年人群中带来了独特的挑战.

研究的目的:

评估意大利威尼托地区罕见疾病的老年人 (65岁以上) 的患病率和特征.
分析这个新兴人口群体的治疗计划.

主要方法:

利用了来自威尼托地区罕见病登记处 (VRRDR) 的基于人口的数据.
估计截至2022年12月31日,老年RD患者的患病率.
分析了老年时的新诊断和从成年期的过渡,以及治疗计划的组成.

主要成果:

截至2022年12月31日,65岁以上的9508人患有RD,占威尼托地区所有RD患者的20.8%.
在老年患者中最常见的RD群体是系统性/风湿性 (27%),神经性 (25%) 和皮肤疾病 (9%).
在老年RD患者中,有1519人有治疗计划,其中神经系统药物 (27.8%),食道/代谢药物 (12.8%) 和抗瘤/免疫调节剂 (11.6%) 是最常见的.

结论:

老年人构成了罕见疾病人口中显著且不断增长的比例.
老年医生和全科医生需要接受培训,以管理老年RD患者的护理需求.
进一步的研究是必不可少的,以确定未满足的需求,并为这群人群制定健康政策.

关键词:

衰老的衰老衰老的衰老职业过渡职业过渡职业过渡流行病学流行病学这就是ORPHA的代码.罕见疾病是一种罕见的疾病.登记处登记处登记处登记处

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