家庭药房系统用于慢性心血管或内分泌疾病患者
1Division of Pharmacoepidemiology, Showa Medical University Graduate School of Pharmacy, Tokyo, Japan.
JAMA network open
|February 23, 2026
概括
日本的家庭药剂师系统 (FPS) 并没有降低老年人的整体死亡或住院风险. 然而,使用FPS可能与该人群中死亡风险略有降低有关.
科学领域:
- 老年学是一门学科.
- 医疗保健服务研究 医疗服务研究
- 药学流行病学 药学流行病学
背景情况:
- 日本的家庭药剂师系统 (FPS) 旨在预防与药物相关的问题,并改善药物管理.
- FPS对患有慢性病的老年患者的死亡率和住院风险的影响仍在调查中.
研究的目的:
- 评估FPS利用与因任何原因死亡或住院的风险之间的关联.
- 为了检查这些风险在老年人 (≥75岁) 患有流行心血管或内分泌疾病.
主要方法:
- 一项大规模的队列研究,利用2015年4月至2024年3月的行政索赔数据.
- 一个普遍的新用户设计将FPS用户与非用户进行比较,采用时间条件倾向得分匹配.
- 考克斯比例危险回归分析了主要结果 (死亡或住院) 和次要结果 (个体组件).
主要成果:
- 该研究包括45,114名患者 (22,557名FPS用户和22,557名非用户),平均年龄为82.8岁.
- 在FPS用户和非用户之间,没有发现FPS用户和非用户 (HR,1.00) 死亡或住院住院的综合风险的显著差异.
- FPS使用者在统计学上显著,虽然轻微,但所有原因死亡风险降低 (HR,0.91),但没有住院治疗.
结论:
- 该研究没有发现FPS使用与慢性疾病老年患者因任何原因死亡或住院的风险降低之间存在关联.
- 结果表明一个潜在的假设,即FPS使用可能与这个特定患者群体的死亡风险略低有关.
- 需要进一步的研究来证实FPS在治疗慢性疾病中的潜在死亡率益处.
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