分子化成像和上升性大动脉疾病在患有双侧大动脉的患者
Jennifer Nash1, Samuel Debono1, Krithika Loganath1
1The University of Edinburgh Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
F18标记的化正子发射断层扫描 (PET) 可以在双管主动脉患者中识别主动脉微化. 低吸收率表明大动脉快速生长,而高吸收率表明大动脉更硬,增长缓慢.
科学领域:
- 心血管成像 - 心血管成像
- 医学物理 医学物理
- 放射化学 放射化学是指辐射化学.
背景情况:
- 双主动脉 (BAV) 患者患有主动脉病需要在预防性手术前进行仔细监测.
- 胸腔大动脉损伤涉及弹性质碎片化,微化和大动脉完整性降低.
- 在BAV患者中预测大动脉直径膨胀仍然是一个临床挑战.
研究的目的:
- 为了研究动脉微化之间的联系,检测到F 18-标记化 ([18F]-NaF) 阳离子发射断层扫描 (PET),和未来的大动脉直径扩张在患者与BAV.
- 探索[18F]-NaF吸收与大动脉硬之间的关系.
主要方法:
- 在三级保健中心进行前性纵向队列研究.
- 患有BAV的参与者接受了基线[18F]-NaF PET/CT和心脏MRI.
- 在24个月内使用心脏MRI评估上升性大动脉直径变化.
主要成果:
- 包括76名BAV患者;56人完成了随访.
- 在基线上升大动脉[18F]-NaF吸收和每年大动脉直径变化 (r = -0.37;P = .005) 之间发现了显著的反相关性.
- 高[18F]-NaF吸收与大动脉硬度增加相关,但不是基线直径.
结论:
- 在BAV患者中,低上升性大动脉[18F]-NaF吸收与大动脉加速生长有关,这表明大动脉壁完整性受到损害.
- 高[18F]-NaF摄入量表明一种更硬,增长缓慢的主动脉表型.
- [18F]-NaF PET成像显示了与BAV相关的胸部动脉损伤中微化表型的非侵入性识别的前景.
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