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相关概念视频

Glycocalyx and its Functions01:14

Glycocalyx and its Functions

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The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
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Matrix Proteoglycans and Glycoproteins01:21

Matrix Proteoglycans and Glycoproteins

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Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
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Proteoglycans01:05

Proteoglycans

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Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
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Protein Glycosylation01:25

Protein Glycosylation

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Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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相关实验视频

Updated: Feb 25, 2026

Glycan Node Analysis: A Bottom-up Approach to Glycomics
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免疫力中的糖甘结合蛋白质

Gabriel A Rabinovich1,2,3, Christoph Rademacher4,5, Mirta Schattner1,2

  • 11Laboratorio de Glicomedicina, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina;

Annual review of immunology
|February 23, 2026
PubMed
概括
此摘要是机器生成的。

糖甘结合蛋白 (GBPs) 通过解释糖甘信号来调节免疫细胞功能. 这些蛋白质的调节失调可能导致免疫功能障碍,突出显示它们作为免疫治疗点的潜力.

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Exploring Protein-Glycan Interactions: Advances in Nuclear Magnetic Resonance
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Exploring Protein-Glycan Interactions: Advances in Nuclear Magnetic Resonance

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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
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相关实验视频

Last Updated: Feb 25, 2026

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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
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科学领域:

  • 免疫学 免疫学 免疫学
  • 葡萄糖生物学 葡萄糖生物学
  • 分子生物学分子生物学

背景情况:

  • 甘氨酸结合蛋白 (GBPs),如盖लेक्ट因,西格莱克和CLR,对于免疫细胞调节至关重要.
  • 这些讲解蛋白解释糖甘编码的信息,以塑造T,B和髓质细胞中的免疫反应.
  • GBPs通过依赖于糖化酶的途径将内在免疫程序与环境和细胞内线索相结合.

研究的目的:

  • 审查细胞机制,通过GBPs控制免疫细胞命运在平衡条件下的细胞机制.
  • 强调GBP在免疫调节中的保留和上下文依赖的作用.
  • 讨论甘氨酸-GBP失调对免疫功能障碍和病理学的贡献,以及它们作为免疫治疗点的潜力.

主要方法:

  • 本综述综合了关于糖甘结合蛋白及其在免疫中的作用的当前文献.
  • 它专注于控制免疫细胞命运和功能的细胞机制.
  • 审查审查了保留和上下文依赖的角色,以及病理影响.

主要成果:

  • GBPs是免疫细胞发育,激活,分化,贩运和平衡的关键调节者.
  • 盖列,西格莱克和CLR在免疫细胞功能中发挥着不同的但相互关联的作用.
  • 由GBPs调解的依赖糖化酶的途径是免疫传感和调制的核心.

结论:

  • 通过解释甘氨酸信息,GBP对于维持免疫平衡至关重要.
  • 糖甘-GBP相互作用的失调有助于免疫病理.
  • 针对涉及GBP的糖免疫检查点,为新型免疫疗法提供了潜力.