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计算流体动力学模拟用于告知癌症治疗方法

Emilie Roncali^1,2, Amirtahà Taebi³

¹1Department of Biomedical Engineering, University of California, Davis, California, USA.

Annual review of biomedical engineering

|February 23, 2026

概括

计算流体动力学 (CFD) 模型为癌症治疗,如跨动脉栓塞等血液流动. CFD有助于优化药物输送和辐射剂量,为个性化癌症治疗铺平道路.

科学领域:

生物医学工程生物医学工程
计算科学计算科学
在瘤学瘤学.

背景情况:

通过血液提供有效的药物和辐射输送对于癌症治疗至关重要.
了解血液和组织中的颗粒运输对于治疗优化至关重要.
计算流体动力学 (CFD) 在现实的条件下模拟血液流动和药物运输.

研究的目的:

审查CFD在癌症治疗中的应用.
探索CFD在跨动脉栓塞,瘤输液和器官芯片系统中的作用.
确定将CFD整合到癌症治疗中的挑战和机会.

主要方法:

关于CFD在癌症治疗中的应用现有文献的审查.
分析CFD在预测微球运输和放射性栓塞剂量分配方面的实用性.
检查CFD在模拟器官芯片系统中的瘤 perfusion 和血管动态中的作用.

主要成果:

在放射栓塞过程中,CFD有助于预测微球运输和剂量分配,有助于节省重要器官.
CFD建模增强了对瘤 perfusion 和血管系统中药物分散的理解.
在器官芯片模型中模拟生物过程时,CFD是有价值的.

结论:

CFD是一个多功能工具,通过模拟血液流动和药物运输来优化癌症治疗.
挑战包括数据要求,计算成本和多尺度建模.
将CFD与成像和AI集成,为个性化癌症治疗提供了未来的潜力.

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