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Updated: Feb 25, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

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一种新的强效和选择性GCN2抑制剂APL-4098通过对线粒体功能的失调具有抗白血病活性

Monica Román-Trufero1, Gavin Whitlock2, Claire Seydoux1

  • 1University Hospital of Lausanne Lausanne Switzerland.

Clinical cancer research : an official journal of the American Association for Cancer Research
|February 23, 2026
PubMed
概括

一种新的GCN2抑制剂APL-4098对急性髓性白血病 (AML) 细胞,包括白血病干细胞 (LSC) 产生强大的抗白血病作用. 这种药物通过向蛋白质稳定体,在AML治疗中显示出显著的前景.

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