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Updated: May 8, 2026

3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression
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在体外居住记忆中使用表皮有机T细胞共同培养系统进行CD8 T细胞分化

Ying Lin1, Julian C Ramprashad2, Elizabeth L Hillier3

  • 1Department of Molecular Microbiology and Immunology, Brown University; Pathobiology Graduate Program, Brown University; ying_lin@brown.edu.

Journal of visualized experiments : JoVE
|February 23, 2026
PubMed
概括

研究人员开发了一种新的有机体共同培养系统,以研究阴道上皮细胞如何影响CD8 T细胞分化. 这种模型有助于理解T细胞如何成为组织内存细胞,这对于屏障部位的免疫至关重要.

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相关概念视频

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...