Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Ligand Binding and Linkage00:49

Ligand Binding and Linkage

4.2K
4.2K
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

5.7K
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
5.7K
Ligand Binding Sites02:40

Ligand Binding Sites

15.4K
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
15.4K
Ligand Binding Sites02:40

Ligand Binding Sites

9.0K
9.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

HERA: a web server for host element reference-based aligner.

Nucleic acids research·2026
Same author

RegRegSEA: a web server for regulatory region set enrichment analysis of epigenomic data.

Nucleic acids research·2026
Same author

Probiotic Lactobacillus rhamnosus mitigates PBC-like features in Mcpip1-deficient mice via modulation of gut-liver crosstalk.

Biochimica et biophysica acta. Molecular basis of disease·2026
Same author

Benchmarking large language models for pathogen-disease classification in post-acute infection syndromes.

Briefings in bioinformatics·2026
Same author

mRNA Sequencing of Limbal Epithelial Cells and mRNA/miRNA Profiling of Limbal Stromal Cells in <i>PAX6</i>-Related Congenital Aniridia.

Cells·2026
Same author

MiRNAs shape mouse age-independent tissue adaptation to spaceflight via ECM and developmental pathways.

Nature communications·2026

相关实验视频

Updated: Feb 25, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.7K

MCPmed:呼吁采用模型上下文协议支持的生物信息网络服务,用于LLM驱动的发现.

Matthias Flotho1,2, Ian Ferenc Diks1,2, Philipp Flotho1

  • 1Chair for Clinical Bioinformatics, Center for Bioinformatics, Saarland University, Saarland University Campus, 66123 Saarland, Germany.

Briefings in bioinformatics
|February 23, 2026
PubMed
概括

生物信息学网络服务器使用模型上下文协议 (MCP) 实现机器可读性. 这增强了生物医学数据的大型语言模型 (LLM) 探索,提高了研究自动化和可重现性.

关键词:
在这里,我们可以使用API API API.地理地质组织 (GEO) 是指地理地质组织.在法学士 (LLM) 课程中.许多CPT的MCP是多元化的.我们的数据库数据库数据库数据库.网络服务器是Web服务器.

更多相关视频

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.1K
An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

4.0K

相关实验视频

Last Updated: Feb 25, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.7K
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.1K
An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

4.0K

科学领域:

  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学
  • 生物医学研究生物医学研究

背景情况:

  • 生物信息学网络服务器对于生物医学研究中的数据探索至关重要.
  • 当前以人为中心的设计限制了人工智能代理的机器可读性.
  • 缺乏机器可操作的接口阻碍了先进的自动化和数据集成.

研究的目的:

  • 为了提高生物信息学Web服务器的大型语言模型 (LLM) 和研究代理的机器可读性.
  • 为生物信息学网络服务开发一个标准化,机器可操作的层.
  • 提高生物医学数据探索中的自动化,可重复性和互操作性.

主要方法:

  • 将模型上下文协议 (MCP) 调整为生物信息学网络服务器后台.
  • 创建了一个标准化,机器可操作的层,将终点与科学概念和元数据联系起来.
  • 在广泛使用的数据库上实现了MCP:GEO,STRING和UCSC细胞浏览器.

主要成果:

  • 通过支持MCP的LLMs,证明了增强的数据探索能力.
  • 成功地将MCP集成到已建立的生物信息数据库中.
  • 展示了改进的机器可读性和与生物信息学资源的交互.

结论:

  • MCP提供了一种标准化的方法,使生物信息学Web服务器能够被机器操作.
  • MCP促进了LLM和研究人员加强对生物医学数据的探索.
  • MCPmed倡议旨在加快采用并为未来的AI驱动研究准备服务.