在T1w/T2w估计的皮质髓与年龄和青春期时间的纵向变化
Theresa W Cheng1, Patrick Mair1, Mark T Curtis2,3
1Department of Psychology, Harvard University, 33 Kirkland St., Cambridge, MA 02138, United States.
Cerebral cortex (New York, N.Y. : 1991)
|February 23, 2026
概括
青春期的时间影响大脑发育,影响男性和女性的皮质内髓 (T1w/T2w) 比率不同. 早期或晚期青春期会影响特定的大脑区域,特别是女性和关联区域.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 放射学 放射学是一门学科.
背景情况:
- 青春期涉及显著的大脑可塑性变化,可能由青春期调节.
- 经验依赖的髓化,以T1加权/T2加权MRI比率 (T1w/T2w) 进行索引,是关键机制.
- 青春期时间对这些大脑变化的影响尚不清楚.
研究的目的:
- 调查青少年年龄,青春期时间和T1w/T2w比率之间的关系.
- 探索青春期定时对大脑发育的性别和区域特异性影响.
主要方法:
- 对9至18岁儿童的神经成像数据的纵向分析 (人类结合体在发展中的项目).
- 贝叶斯的层次性通用添加模型被采用.
- 检查了T1w/T2w比率作为皮层内髓的代理.
主要成果:
- 与年龄相关的T1w/T2w变化遵循一个传感运动到关联的皮质轴.
- 青春期的时间解释了T1w/T2w变异的1.8%.
- 早期青春期与女性的感觉运动和协会区域的T1w/T2w变化有关;晚期青春期与两性协会区域的T1w/T2w较高有关.
结论:
- 青春期的时间,与年龄一起,是青少年大脑成熟的一个重要因素.
- 性别和区域特异性影响凸显了青春期和神经发育之间的复杂相互作用.
- 需要进一步的研究来确认这些发现,并探索认知和心理社会相关性.
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