定义儿科肝移植协会 (SPLIT) 的研究议程:德尔菲共识项目
Sharad I Wadhwani1,2, Pooja Reddy Spector3, Amy G Feldman4
1Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA.
Hepatology communications
|February 23, 2026
概括
专家更新了儿科肝移植 (LT) 研究重点,以改善长期结果. 关键领域包括等候名单分配,免疫抑制和器官保存,以改善儿童移植后的生存和健康.
科学领域:
- 儿科移植 儿科移植
- 肝病学 肝病学是一种肝病学.
- 手术研究的研究.
背景情况:
- 儿科肝移植 (LT) 接受者长期表现不佳,仅有三分之一的儿童在10年后仍然没有发病.
- 儿科肝移植协会 (SPLIT) 之前的一个研究议程已经有十多年了.
- 需要一个更新的,以共识驱动的研究议程来指导未来的儿科LT研究和资金.
研究的目的:
- 识别和优先考虑儿童肝移植的整个领域的关键研究需求.
- 为儿科肝移植学会 (SPLIT) 建立一个以共识为导向的研究议程.
主要方法:
- 采用了经过修改的Delphi共识流程,涉及来自SPLIT的多学科专家.
- 进行了三轮专家输入和评级,从开放式提交开始,最终重新评级了42个优先级陈述.
- 共识被定义为在9点的利克特等级上,中位重要度评分为7或更高.
主要成果:
- 在7个领域确定了46个高优先级的研究主题,包括等候名单管理,移植准入,外科手术后护理,免疫抑制,并发症,长期健康和特殊人群.
- 首要任务包括开发更新的LT等候名单分配工具,确定免疫抑制管理的生物标志物,并制定新的器官保存策略.
- 69名专家参与了三轮共识,在三轮共识中,消耗率低 (<30%).
结论:
- 确定了46个研究重点,代表了儿科LT研究的未来方向.
- 这一共识议程为研究人员,资助者和医疗保健系统提供了一份路线图,以提高儿科LT接受者的生存率和终身福祉.
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