相关实验视频

Updated: Feb 25, 2026

An In Vitro Skin Irritation Test SIT using the EpiDerm Reconstructed Human Epidermal RHE Model

An In Vitro Skin Irritation Test SIT using the EpiDerm Reconstructed Human Epidermal RHE Model

Published on: July 13, 2009

基于容量传感器的人工角质层用于皮肤刺激植物性杀虫剂产品的评估和一种去刺激的配方

Yun-Hsuan Cheng¹, Po-Chung Chen², Hung-Yu Chen³

¹Department of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

|February 23, 2026

概括

植物性驱虫剂可能会引起皮肤刺激. 一种新的电子人工角层 (eASC) 表明,状配方显著降低了这种刺激潜力,提供了更安全的局部植物产品.

科学领域:

皮肤病学皮肤病学
生物相容材料科学生物相容材料科学
生物传感技术的技术

背景情况:

植物性驱虫剂是 DEET 等合成选项的受欢迎的环保替代品.
这些驱虫剂中的植物成分可能会引起皮肤刺激和过敏反应.
有限的研究存在于植物驱虫剂的体外皮肤刺激潜力.

研究的目的:

为了评估商业植物性昆虫驱虫剂的皮肤刺激潜力.
为了研究细胞配方对驱虫剂诱导的皮肤刺激的缓解作用.
为了验证一种新的电子人工角层 (eASC),用于刺激测试.

主要方法:

利用带有脂质膜的电容生物传感系统创建一个eASC.
在暴露于驱逐产品时,测量了界面电容的实时变化.
评估了eASC对商业植物驱虫剂和状配方的电介质反应.

主要成果:

一些植物性驱虫剂引起了显著的膜容量变化,表明皮肤屏障受损和刺激.
使用PEG-40化麻油进行微化显著降低了介电反应.
eASC平台成功检测出刺激潜力和配方的缓解作用.

结论:

配方策略,如微粒化,对于减少植物驱虫剂的皮肤病风险至关重要.
eASC平台提供了一种具有成本效益的,无指标的方法,用于快速的体外皮肤刺激查.
这项技术支持产品开发和局部植物产品的监管评估.

关键词:

植物性昆虫驱除剂植物性昆虫驱除剂人工层的角质 (corneum) 是一个人造层.电容传感器是一种传感器.兰诺林兰诺林是一个皮肤刺激皮肤刺激

更多相关视频

Eye Irritation Test EIT for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial RhCE Tissue Model

Eye Irritation Test EIT for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial RhCE Tissue Model

Published on: August 23, 2015

Preparation of Keratin Hydrolysate from Chicken Feathers and Its Application in Cosmetics

Preparation of Keratin Hydrolysate from Chicken Feathers and Its Application in Cosmetics

Published on: November 27, 2017

相关概念视频

Sensory Functions of the Skin

Sensory Functions of the Skin

The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...