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对呼吸中与衰老相关的生物标志物的审查
Kartini I Vosshage1, James R Swift1, Ayoung Kim1
1Department of Chemistry, Loughborough University, Loughborough Leicestershire United Kingdom LE11 3TU.
Ageing research reviews
|February 23, 2026
概括
确定可靠的衰老生物标志物对于早期干预至关重要. 呼出的挥发性有机化合物 (VOC) 显示出作为非侵入性衰老诊断的前景,通常检测到,异烯和.
科学领域:
- 生物标志物 生物标志物
- 老年学是一门学科.
- 分析化学 分析化学
背景情况:
- 人口老龄化带来了医疗保健挑战,需要监测生理衰退的方法.
- 衰老是多因素的,受到生活方式,环境和健康的影响,突出了对可靠生物标志物的需求.
- 呼出的气息挥发性有机化合物 (VOC) 提供了一种非侵入性的方法来评估生理状态.
研究的目的:
- 审查关于呼气中挥发性有机化合物的年龄相关变化的研究.
- 分析分析方法,化合物重叠和这些VOC的机械相关性.
- 探索呼吸中的VOCs作为衰老的生物标志物的潜力.
主要方法:
- 在四个数据库 (2000-2024) 中进行了系统的文献搜索.
- 关键词包括"呼吸"",挥发性有机化合物 (VOCs) "和"衰老".
- 检查了11项研究,调查了年龄相关的VOC变化.
主要成果:
- 发现的常见的与年龄相关的VOC包括,异烯和.
- 由于不同的方法,观察到功能组趋势的变化.
- 几种VOC与与衰老相关的途径有关 (例如NF-κB,Nrf2-Keap1,PI3K/Akt).
结论:
- 目前还没有单一的气息衰老生物标志物出现.
- 呼吸VOC分析显示了对非侵入性衰老诊断的潜力.
- 将先进的分析与人工智能的整合可能会导致基于呼吸的强大衰老诊断.
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