周周重复性横性磁性刺激增强了最小意识状态患者的功能连接性
Xiao Yan1, Zilong Zhu1, Jubao Du1
1Department of Rehabilitation Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China.
Neuroscience
|February 23, 2026
概括
周周重复性横磁刺激 (rTMS) 在最小意识状态 (MCS) 患者中显著改善了意识恢复. 这种非侵入性大脑刺激增强了大脑的功能连接,特别是在前端对象网络内,与改善的临床分数相关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 康复医学 康复医学 康复医学
背景情况:
- 意识障碍源于大脑功能连接受损.
- 恢复损坏的连接是恢复意识的关键.
- 最小意识状态 (MCS) 在诊断和治疗方面存在挑战.
研究的目的:
- 为了研究表层重复性横磁刺激 (rTMS) 对MCS患者大脑功能连接性的影响.
- 用电生理学分析评估rTMS在促进意识恢复方面的有效性.
- 探索由rTMS促进的意识恢复的潜在神经机制.
主要方法:
- 24名患有MCS的患者被随机分为真实或假的rTMS组.
- 真正的rTMS针对的是头顶皮层 (10 Hz,90% RMT);假组接受了安慰剂刺激.
- 休息状态EEG和昏迷恢复尺度修订 (CRS-R) 评分在治疗前和治疗后进行测量.
- 阶段锁定值 (PLV) 分析了功能连接,包括默认模式网络 (DMN) 和前端对称网络 (FPN).
主要成果:
- 真正的rTMS组在治疗后的CRS-R得分显著改善.
- 真正的rTMS导致了PLV,DMN,FPN和FPN-DMN连接的增加.
- 在假装组中,没有观察到CRS-R或EEG测量的显著变化.
- FPN的变化与CRS-R得分的改善正相关.
结论:
- 周围的rTMS通过加强大规模的大脑网络,增强MCS患者的意识恢复.
- 该疗法通过加强功能性大脑连接和激活神经网络来促进恢复.
- 前线对称网络的功能连接与意识恢复的早期阶段密切相关.
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