迷幻医学:机制,证据和转化到实践中
Edward Jacobs1, Zarmeen Zahid1, Jared Hinkle2
1Center for Psychedelic and Consciousness Research, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
概括
像psilocybin和MDMA这样的迷幻疗法对精神疾病有很大的希望,但临床转化和可扩展性仍然存在挑战. 需要进一步的研究来标准化协议,并确保在不同的人群中获得好处.
科学领域:
- 精神病学和神经科学 精神病学和神经科学
- 药理学 药理学是指药理学的学科.
- 临床心理学 临床心理学
背景情况:
- 迷幻疗法,包括psilocybin和MDMA,在精神疾病中获得了显著的临床兴趣.
- 这些疗法涉及药物管理与心理治疗相结合,潜在的机制涉及神经电路和情绪处理.
研究的目的:
- 审查目前在精神疾病中使用psilocybin和MDMA的证据.
- 检查心理治疗辅助疗法的拟议作用机制.
- 确定这些治疗的临床转化和可扩展性的挑战.
主要方法:
- 对西和MDMA的最新证据进行系统审查.
- 对拟议的生物和心理机制进行分析.
- 评估临床试验中的方法限制和可扩展性挑战.
主要成果:
- 最强有力的证据支持治疗耐药抑郁症的 псилоцибин和治疗创伤后应激障碍的MDMA.
- 新出现的数据表明,潜在的物质使用障碍和危及生命的疾病中的痛苦.
- 方法限制 (例如,解盲,可变协议) 和可扩展性问题 (密集支持) 复杂解释和实施.
结论:
- 迷幻疗法显示出治疗的希望,但在标准化,可扩展性和在不同人群中展示持久益处方面面临障碍.
- 解决方法上的局限性和制定实施准则对于未来的研究和临床采用至关重要.
- 该领域必须平衡治疗潜力与监管和医疗保健系统限制.
相关概念视频
Hallucinogens and Psychedelics
791
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
791
CNS Stimulants: Psychedelic Agents
885
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
885
Altered States of Awareness
1.3K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.3K
The Placebo Effect
6.9K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.9K
An Overview of Psychoactive Drugs
674
Psychoactive drugs impact brain function, influencing perception, mood, consciousness, cognition, and behavior. These substances are grouped based on their effects and the mechanisms by which they act.
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
674
The Scientific Method
66.2K
Research is what makes the difference between facts and opinions. Facts are observable realities, and opinions are personal judgments, conclusions, or attitudes that may or may not be accurate. In the scientific community, facts can be established only using evidence collected through empirical research.
66.2K


