在最小侵入性心肌门修复中使用Custodiol保护心肌的安全性:一项日本单中心的回顾性比较,与传统椎切除修复中的血液心肌的比较
Hiroaki Aizawa1, Akihiro Yoshitake1, Yuki Katsunori2
1Department of Cardiovascular Surgery, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan.
概括
在米特拉门修复中,Custodiol提供了与冷血心脏的可比心肌保护. 这项研究发现,在微创手术中,使用Custodiol降低了肌酸激酶-MB水平.
科学领域:
- 心脏病学 心脏病学
- 心脏外科手术 心脏外科手术
- 心脏的解决方案 心脏的解决方案
背景情况:
- 关于亚洲人群中Custodiol对最小侵入性中枢修复的安全性存在有限的数据.
- 需要与使用冷血心肌的传统开放修复方法进行比较.
研究的目的:
- 为了比较Custodiol与重复性冷血性心脏的疗效.
- 评估心肌保护在最少侵入性与开放性心肌门修复之间.
主要方法:
- 追溯分析98名最小侵入性 (Custodiol) 和70名开放性 (冷血心肌) 中枢修复患者.
- 主要终点:肌酸激酶-MB水平和左心室喷射率 (LVEF).
- 用于术前和术后LVEF评估的心声学.
主要成果:
- 在微创手术组 (45.0 U/L) 和开放修复组 (60.7 U/L; p <0.001) 中,在手术后48小时内显著降低肌酸酶-MB峰值水平.
- 这种差异在排除 Maze 或 PVI 程序 (42.4 vs 50.0 U/L; p = 0.009) 之后仍然存在.
- 手术前和手术后的LVEF在两组之间是可比的 (p > 0.20).
结论:
- 卡斯托迪奥尔提供心肌保护,相当于重复的冷血心脏.
- 使用Custodiol进行最小侵入性关门修复是一种安全有效的替代方案.
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