表面活性离子基于液体的微乳液的物理化学表征,用于增强通过皮肤输送的鲁
Mina Tanigawa1, Chew Ben Kiat1, Yukihiro Ono2
1Division of Applied Chemistry, Graduate School of Engineering, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
Chemical & pharmaceutical bulletin
|February 23, 2026
概括
这项研究开发了新型微乳液,使用深层浸泡溶剂和表面活性离子液体,以增强通过皮肤输送 rutin. 随着特定的微乳液配方, rutin 的皮肤透性显著增加.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 有效的透皮药物输送仍然是一个挑战.
- 鲁是一种黄类化合物,具有治疗潜力,但穿透皮肤的能力较差.
- 微乳液 (ME) 为药物输送提供了一个有前途的工具.
研究的目的:
- 开发一种新型的微乳液 (ME) 系统,以有效地通过皮肤递送 rutin.
- 为了研究深层性溶剂 (DES) 和表面活性离子液体 (SAILs) 在ME配方中的作用.
- 评估已开发的ME的结构特征和皮肤透性.
主要方法:
- 使用胆化/聚乙烯甘醇 (PEG) 200作为DES和1--3-甲基化 (Cn mimBr) 作为SAILs的ME的配方.
- 使用小角度X射线散射 (SAXS) 和传输电子显微镜 (TEM) 的结构特征.
- 通过传统的油中的水 (W/O) MEs和基于SAIL的MEs进行皮肤透性的体外评估.
主要成果:
- 具有C10 mimBr和C12 mimBr的ME表现出圆柱形结构,而C16 mimBr形成球形结构.
- 基于SAIL的ME证明了鲁丁的显著增强的皮肤透性 (约. 与传统的W/O MEs相比,这些企业的销售额 (W/O MEs) 高6.8倍.
- 在SAIL中选择基链长度影响了ME结构和鲁丁透性.
结论:
- 基于SAIL的微乳液是有效的载体,可以增强通过皮肤递送的 rutin.
- 由SAILs决定的ME的结构形态在药物透中起着至关重要的作用.
- 这种配方策略对开发先进的透皮药物递送系统具有前景.
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