酸可以通过激活肉的PPAR和CYP7A1通路来改善生长性能和脂质代谢和胆酸水平,部分是通过激活肉的PPAR和CYP7A1通路
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Updated: Feb 25, 2026

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Isolation of Preadipocytes from Broiler Chick Embryos
Published on: August 4, 2022
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Fei Long1, Zhangbo Lou1, Jun Qi1
1College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
Journal of the science of food and agriculture
|February 23, 2026
概括
通过食酸 (FA) 补充,通过激活关键通路,改善了 brojler 的生长和脂质代谢. 商业 brojlers 建议使用 100 mg/kg FA 的剂量来提高性能和健康.
科学领域:
- 动物营养 动物营养
- 生物化学 生物化学
- 微生物学 微生物学
背景情况:
- 肉的高能量,高蛋白饮食导致脂肪沉积和代谢障碍.
- 酸 (FA) 是一种类化合物,显示出改善肉健康的潜力.
- 这项研究调查了FA对肉生长,脂质代谢,胆酸合成和肠道微生物群的影响.
研究的目的:
- 为了评估食中的酸 (FA) 对 brojlers 的生长性能的影响.
- 评估FA对脂质代谢和胆酸合成的影响.
- 分析FA补充引起的肠道微生物组合的变化.
主要方法:
- 640只雄性肉被食了0,50,100,150或200毫克/公斤FA的饮食42天.
- 测量了生长性能,肝脂水平以及基因/蛋白质表达 (AMPK,PPARγ,CYP7A1).
- 用16S rRNA测序和Cecal代谢学分析了肠道微生物群.
主要成果:
- 饮食FA线性增加了平均每日益,并降低了肝脏甘油三,总胆固醇和LDL胆固醇.
- FA上调肝脏AMPK和PPARγ,并增加CYP7A1的表达,导致胆酸水平更高.
- FA改变了肠道微生物群,增加了有益的蓝菌和艾森伯吉拉,同时减少了菌和细菌.
结论:
- 酸增强肉的平均每日增益,并通过AMPK/PPAR激活改善脂质代谢.
- 通过上调CYP7A1的表达,FA会增加胆酸水平.
- 建议在商业肉中补充100毫克/公斤FA.
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