脂肪性肝病与慢性病之间的关联:一个元分析和孟德尔随机化研究,突出了代谢性并发症
Xiang Ji1,2, Jinguo Jiang1,2, Yunyun Liu3
1Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Nutrition & diabetes
|February 23, 2026
概括
脂肪性肝病 (SLD),包括MAFLD,NAFLD和MASLD,与慢性病 (CKD) 风险增加有关. 然而,代谢因素,而不是SLD本身,似乎是导致CKD发展的原因.
科学领域:
- 肝病学和病学 肝病学和病学
- 代谢疾病 代谢疾病
- 流行病学 流行病学
背景情况:
- 脂肪性肝病 (SLD),包括与代谢相关的脂肪性肝病 (MAFLD),非酒精性脂肪性肝病 (NAFLD) 和与代谢功能障碍相关的脂肪性肝病 (MASLD) 以及慢性病 (CKD) 是全球重要的健康挑战.
- 代谢因素是MAFLD和MASLD定义的核心,并可能影响它们与CKD的关联.
研究的目的:
- 更新关于SLD和CKD风险之间的关联的元分析.
- 进行两样本的门德尔随机化 (MR) 分析,以调查SLD和代谢因素在CKD中的因果作用.
主要方法:
- 在PubMed,Embase和Web of Science的系统文献搜索到2024年11月.
- 使用随机效应模型进行元分析,以 95% 置信区间 (CI) 的概率比率 (OR) 进行聚合.
- 采用逆变量加权 (IVW) 方法和灵敏度分析的两样 MR 分析.
主要成果:
- 对34项研究 (3,783,136名参与者) 的分析显示,MAFLD,NAFLD和MASLD与CKD之间存在显著的积极关联.
- 核磁共振分析显示,SLD对CKD风险没有因果关系.
- 基因预测的代谢因素 (BMI,腰围,2型糖尿病,血压,脂质) 与CKD风险增加有显著的关联.
结论:
- SLD与CKD风险增加有显著的相关性.
- 代谢功能障碍,而不是SLD本身,似乎是CKD风险的主要驱动因素.
- 早期查和对SLD患者代谢健康的干预对于减轻CKD负担至关重要.
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