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Updated: Feb 25, 2026

Pooled shRNA Library Screening to Identify Factors that Modulate a Drug Resistance Phenotype
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在AML中,布苏尔方耐药性与线粒体拷贝数和脂质代谢的变化有关

Vid Mlakar1, Simona Jurković Mlakar2,3, Yvonne Gloor2

  • 1CANSEARCH Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland. vid.mlakar@unige.ch.

Scientific reports
|February 23, 2026
PubMed
概括

急性髓性白血病 (AML) 细胞中的布苏尔方耐药性与线粒体DNA复制数 (mtDNA-CN) 的增加有关. 这项研究揭示,布苏尔 (BU) 耐药性涉及mtDNA-CN和基因表达的变化,提供潜在的治疗点.

关键词:
MTND1 一个国家.获得的化学电阻急性髓性白血病是什么?急性髓性白血病是什么?布苏尔夫人 布苏尔夫人 布苏尔夫人胆固醇 胆固醇 胆固醇赛塔拉宾可以作为一种药物.IC50 IC50 IC50 IC50 IC50 IC50 IC50 IC50 IC50 IC50 IC50 IC50 IC50这是MOLM-13号.线粒体中的线粒体.

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