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将B细胞分化模型与现实世界的数据集成,为系统性硬化症中抗体分泌细胞枯竭的决定因素提供了信息

Tomohisa Nakada1, Ryuta Saito1, Sho Ishigaki2

  • 1Discovery Technology Laboratories, Research Division, Tanabe Pharma Corporation, Yokohama, Japan.

CPT: pharmacometrics & systems pharmacology
|February 23, 2026
PubMed
概括

这项研究模拟了系统性硬化症 (SSc) 中B细胞对CD19和CD20疗法的反应. 高血细胞与血细胞比率预测CD20治疗的反应不佳,与CD19治疗不同.

关键词:
免疫学 免疫学 免疫学基于机制的药理动力学-药理动力学.一个单克隆抗体.个性化医疗是个性化的医疗.基于生理学的药理动力学.量化药理学 量化药理学系统药理学 药理学

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