在接受腹部手术的癌症患者多模式预康计划后,功能能力和身体组成的变化
Luuk D Drager1, Baukje van den Heuvel2, Dieuwke Strijker2
1Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands. Luuk.drager@radboudumc.nl.
Annals of surgical oncology
|February 23, 2026
概括
在接受腹部手术的癌症患者中,预康复显著改善了功能能力和身体组成. 然而,这些收益并没有在术后长期维持,这凸显了需要持续支持的需要.
科学领域:
- 在瘤学瘤学.
- 运动生理学 运动生理学
- 外科手术的结果
背景情况:
- 手术前的功能能力和身体组成会影响癌症患者的手术结果.
- 预康复的长期影响和运动剂量反应仍然不清楚.
研究的目的:
- 在预康复期间和之后调查功能能力和身体组成的变化.
- 在接受腹部癌症手术的患者中评估运动剂量-反应关联.
主要方法:
- 包括F4S PREHAB试验 (2021年3月至2024年4月) 的816名患者,他们接受了针对癌症的选择性腹部手术.
- 功能能力 (氧气吸收峰值,运动能力,肌肉力量) 和身体组成在基线,预康复后和术后3个月被评估.
- 线性混合模型被用来分析随时间的变化和剂量-反应关联.
主要成果:
- 在预康复后,观察到高峰氧气吸收,运动能力,肌肉强度,体重和无脂肪质量的显著改善.
- 功能能力指标在术后恢复或下降到基线值以下.
- 发现了运动剂量与反应的关联,根据瘤类型,新辅助疗法,营养不良风险和遵守情况而有所不同.
结论:
- 前期康复改善了腹部癌症手术患者的功能能力和身体组成.
- 这些改善通常不会在术后持续下去.
- 未来的研究应该探索有针对性的方法和与术后康复策略的整合.
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