对精神分裂症患者面部和情绪处理网络的失联性进行系统审查
Amritha Harikumar1,2,3, Junqiang Dai4,5, Elaine F Walker6
1Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory, Atlanta, GA, USA. aharikumar1@student.gsu.edu.
Cognitive, affective & behavioral neuroscience
|February 23, 2026
概括
精神分裂症患者表现出面部处理缺陷,影响社会认知. 大脑网络的不连接,特别是在执行和默认模式网络中,与临床症状和社会缺陷有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 精神分裂症影响全球2000万,其特点是社会互动缺陷.
- 面部处理障碍严重阻碍了精神分裂症患者的社会认知.
- 现有的研究广泛使用fMRI进行面部处理,但对网络失联和临床症状的系统审查很少.
研究的目的:
- 系统地审查大脑网络,它们在精神分裂症亚型中的失联性,以及它们与临床症状的关系.
- 研究社会认知功能障碍,面部处理网络和三重网络等大规模大脑网络之间的联系.
- 综合fMRI关于精神分裂症中面部和情绪处理的研究结果.
主要方法:
- 使用PubMed,PsycINFO,科学网络和谷歌学者对英语语言研究 (2020-2025) 的系统审查.
- 纳入标准:关于精神分裂症患者面部/情绪处理的fMRI研究 (休息状态或基于任务) (不包括FEP重点).
- 审查了九篇相关文章,分析了神经网络,失联模式和临床症状相关性.
主要成果:
- 在第一发精神病 (FEP) 患者中,阳性和阴性综合征升高量表 (PANSS) 的阳性得分与社会认知缺陷相关.
- 在执行功能,思维理论 (ToM) /思维,默认模式,边缘和视觉感知网络中观察到一致的失联.
- 精神分裂症亚型表现出明显的失联模式,影响社会认知,同情,情绪处理和面部/情绪识别.
结论:
- 精神分裂症的社会认知缺陷与识别和处理负面情绪面孔的困难密切相关.
- 关键大脑网络的失联是精神分裂症亚型中社会认知障碍的基础.
- 进一步的研究应该探索与精神分裂症亚型及其神经相关的创伤,自杀倾向和炎症等因素.
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