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激素替代疗法的对肝脏和心脏代谢结果的影响在绝经前期的MASLD中

Alex E Henney^1,2,3, Jo Wilson¹, David R Riley^1,2,3

¹Department of Cardiovascular and Metabolic Medicine, University of Liverpool, Liverpool, UK.

Liver international : official journal of the International Association for the Study of the Liver

|February 23, 2026

概括

激素替代疗法 (HRT) 可能会降低患有代谢功能障碍相关脂肪性肝病 (MASLD) 的女性的风险. 这项研究发现,HRT在五年内减少了主要肝脏和心脏代谢疾病的风险.

科学领域:

肝病学和内分泌学.
妇女健康妇女健康
代谢性疾病研究研究

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一种普遍存在的全球性肝病.
更年期会加剧肝脏脂肪沉积,增加肝脏和心血管疾病的风险.
激素替代疗法 (HRT) 在临床前研究中显示出降低这些风险的潜力.

研究的目的:

调查HRT与患有MASLD的绝经前妇女的主要不良肝脏结果 (MALO) 和心脏代谢疾病的风险之间的关联.
为了比较开始HRT的女性与未接受治疗的对照女性的结果.

主要方法:

使用 TriNetX 全球联合研究网络进行的回顾性队列研究.
包括已有MASLD和至少一个代谢综合征特征的绝经前妇女 (40-65岁).
1:1的倾向分数匹配与HRT使用者与对照者进行了比较,分析了5年的结果.

主要成果:

HRT与MALO风险显著降低有关,包括,自发性细菌性腹膜炎和肝硬化.
HRT还降低了2型糖尿病 (T2D) 和主要心血管不良事件 (MACE) 的风险.
没有乳腺癌或静脉血栓栓塞 (VTE) 的风险增加;观察到子宫内膜癌风险降低.

结论:

在患有MASLD的女性中,治疗更年期前症状的HRT与较低的5年肝脏和心脏代谢疾病风险有关.
这些发现支持通过临床试验进一步调查,以确认HRT的保护作用.

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