血清pyridoxal 5'-phosphate与石风险之间的关联:中性粒细胞计数作为部分媒介
Di Chen1, Wenju Fan2, Qiufeng Zhou3
1Department of Urology, The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
European journal of medical research
|February 24, 2026
概括
较高的血清pyridoxal 5'-phosphate (PLP) 水平与降低结石 (KS) 风险有关,特别是在特定的人口结构中. 中性粒细胞炎症可能会调解PLP和KS之间的这种保护性关联.
科学领域:
- 生物化学 生物化学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养科学 营养科学
背景情况:
- 结石 (KS) 是一个严重的健康负担.
- 血清pyridoxal-5-phosphate (PLP) 是维生素B6的活性形式.
- 需要进一步调查PLP水平与KS风险之间的关系.
研究的目的:
- 分析血清PLP水平与患结石风险之间的关联.
- 探索免疫炎症标志物在这种关系中的潜在调解作用.
- 通过网络药理学来调查潜在的分子标.
主要方法:
- 利用了国家健康和营养检查调查 (2007-2010) 的数据.
- 采用加权多变量逻辑回归,限制立方线 (RCS) 和子组分析.
- 进行调解分析和网络药理学以阐明机制.
主要成果:
- 血清PLP水平升高 (Q4与Q1) 与患结石的风险显著降低相关 (OR:0.66).
- 在血清PLP和KS风险之间观察到非线性负相关性.
- 保护作用在BMI为25-29.9公斤/平方米,没有糖尿病或高血压的个体中最为明显.
- 在PLP-KS风险关联中,中性粒细胞被确定为调解者 (5.61%效果).
- 网络药理学表明,PLP通过HIF和化学激素信号通路影响KS.
结论:
- 较高的血清PLP水平与特定人群 (BMI 25-29.9,没有糖尿病,没有高血压) 的结石风险降低有关.
- 炎症过程,特别是涉及中性粒细胞,可能在PLP和结石形成之间的关系中发挥中介作用.
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