细菌病原体和抗生素耐药性模式在儿科尾炎:对抗生素选择的影响
Simeon Barth1, Markus Hufnagel1, Lennard Forßmann2
1From the Division of Pediatric Rheumatology and Clinical Infectious Diseases, Department of General Pediatrics and Adolescent Health, Faculty of Medicine, Children's Hospital, Medical Center, University of Freiburg, Freiburg, Germany.
塞福洛キシ姆/美트로尼达对无并发症的尾炎有效,而皮佩拉西林/塔扎巴克坦适用于德国儿科患者的复杂病例. 这项研究分析了局部耐药性模式,以优化急性尾炎的抗生素治疗.
科学领域:
- 儿科外科手术 儿科外科手术
- 传染病 传染病 传染病
- 临床微生物学 临床微生物学
背景情况:
- 急性尾炎是全球常见的外科紧急情况,尾切除术是标准的治疗方法.
- 术期间使用抗生素来减少并发症,但病原体耐药性在地理位置上有所不同.
- 了解局部耐药性模式对于在急性尾炎中有效选择抗生素至关重要.
研究的目的:
- 为了分析德国转诊中心的儿科患者急性尾炎的局部抗生素耐药性模式.
- 为指导对急性尾炎的术后抗生素治疗的优化.
主要方法:
- 181名儿科患者的回顾性队列分析,其中包括经组织学确认的尾炎患者.
- 分析包括症状,实验室,成像和手术内微生物学的结果.
- 进行了病原体鉴定和抗生素敏感性测试.
主要成果:
- 大肠杆菌,Streptococcus anginosus群和Bacteroides fragilis是最常见的病原体.
- 对安培林/苏尔巴克坦,赛福洛キシ姆/赛弗特里亚克森和西普罗夫洛克萨观察到高耐药率.
- 对于塞福洛キシ姆/美特罗尼达,皮佩拉西林/塔扎巴克坦和美罗,观察到的耐药性较低.
结论:
- 在这个队列中,塞福洛キシ姆/美特罗尼达是无并发性尾炎的可行选择.
- 皮佩拉西林/塔扎巴克坦似乎足以治疗复杂的尾炎病例.
- 当地耐药性数据对于量身定制儿童尾炎抗生素策略至关重要.
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