营养干预和重症监护后综合征:一个叙述性回顾
Claire Dupuis1,2, Jean-Charles Preiser3, Rebecca A Busch4
1Department of Intensive Care, HUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
概括
严重疾病引起的ICU-AW导致肌肉损失,影响恢复和生存. 个性化营养,以生物标志物和特定阶段的养为指导,是管理ICU-AW和改善患者结果的关键.
科学领域:
- 关键护理医学 关键护理医学
- 营养科学 营养科学
- 生理学 生理学 生理学
背景情况:
- 危急疾病的长期后果,包括身体,认知和心理障碍,正在引起人们的注意.
- 在ICU获得的弱点 (ICU-AW) 是由炎症,代谢,营养不良和不运动驱动的主要身体障碍.
- 肌肉消耗显著阻碍恢复,导致失去独立性,降低生活质量和增加死亡率.
研究的目的:
- 为了检查关键疾病中肌肉消耗的病理生理学.
- 审查营养在调节结果中的作用,包括重症监护后综合征.
- 讨论了解营养,生物标志物和个性化营养策略的最新进展.
主要方法:
- 现有文献的叙述性审查.
- 分析肌肉衰竭的病理生理学.
- 综合了最近关于营养和结果的数据.
主要成果:
- 营养不良是恢复的关键决定因素,但由于过度养/营养不良的风险,营养管理是复杂的.
- 建议采用个性化的营养策略,从低热量养开始,逐步推进到高能量,富含蛋白质的支持.
- 最近的证据表明,应谨慎避免过早摄入过多的蛋白质;监测工具和辅助策略,如免疫营养素和早期康复,显示出有前途.
结论:
- 优化营养对于缓解ICU-AW和改善患者康复至关重要.
- 需要进一步的研究来确定辅助策略的作用和风险-收益概况.
- 开发强大的生物标志物对于指导在重症监护中的个性化营养干预措施至关重要.
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