从免疫学的角度来看,动脉样硬化和肺癌之间的因果关系的潜在解释:孟德尔的随机化和转录学研究
Peinan Zhang1, Xiaozhang Bao, Xike Wu
1College of Life Science, Zhejiang Chinese Medical University, Hangzhou, China.
Medicine
|February 24, 2026
概括
根据孟德尔的随机化,动脉样硬化 (AS) 可能会降低肺癌风险. 一个预后模型确定了与AS相关的基因,影响肺癌预后和瘤中的免疫细胞透.
科学领域:
- 心血管研究研究心血管研究
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 动脉样硬化 (AS) 和肺癌经常同时发生,影响全球死亡率.
- 关于它们之间的关系的观测研究受到混因素的限制.
- 需要严格的因果推断来理解AS与肺癌的联系.
研究的目的:
- 使用孟德尔随机化 (MR) 调查AS和肺癌之间的潜在因果关系.
- 开发一种与AS相关的肺癌预后模型.
- 分析不同肺癌风险组的免疫细胞透.
主要方法:
- 门德尔随机化 (MR) 分析用于因果推断.
- 公共数据集的转录分析.
- 用于预后模型构建的LASSO-Cox回归.
- 用于免疫透分析的ESTIMATE和ssGSEA算法.
主要成果:
- 核磁共振分析显示,AS和肺癌之间存在显著的逆因果关系 (P=.01,OR=0.896).
- 使用CD52,FABP5和FCGR3A的预后模型将肺癌患者分为不同的风险组.
- 低风险组表现出更高的免疫细胞透,特别是中性粒细胞和巨细胞.
结论:
- 对AS的遗传倾向与肺癌风险降低有关.
- 慢性炎症与AS和肺癌有关,AS可能通过免疫媒介抑制瘤的进展.
- 与AS相关的基因影响肺癌预后和瘤免疫微环境.
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