血清二碳酸盐与流感重症患者30天死亡率之间的关联:来自MIMIC-IV数据库的回顾性队列研究
Yingxiu Huang1, Ting Ao, Ming Hu
1Department of Infectious Disease, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Medicine
|February 24, 2026
概括
流感患者在重症监护室 (ICU) 的血清二碳酸盐水平较高,与更好的生存率有关. 这一发现表明二碳酸盐可能是预测危急流感病例结果的关键指标.
科学领域:
- 临界护理医学 临界护理医学
- 传染性疾病 传染性疾病
- 生物化学 生物化学
背景情况:
- 流感是全球重要的健康问题,特别是在重症监护室 (ICU) 的患者身上.
- 血清二碳酸盐对死亡率的作用已知,但其对严重流感的具体影响尚未明确.
研究的目的:
- 为了研究血清二碳酸盐水平和入住ICU的危急性流感患者的30天死亡率之间的联系.
主要方法:
- 一项使用MIMIC-IV v2.2数据库数据的回顾性队列研究.
- 对276名严重流感患者的分析,重点关注ICU入院后24小时内血清二碳酸盐水平.
- 使用单变量/多变量考克斯回归和受限立方线回归进行关联分析.
主要成果:
- 在研究队列中,30天死亡率为15.5%.
- 较高的血清二碳酸盐水平独立地与较低的30天死亡率相关 (aHR 0.9;P=.011).
- 血清二碳酸盐≥26mEq/L的患者与<22mEq/L (aHR 0.38;P=.026) 的患者相比,死亡风险显著降低.
结论:
- 在ICU入院时血清二碳酸盐水平升高独立地与危急性流感患者30天死亡率降低有关.
- 血清二碳酸盐可以作为流感相关的严重疾病的预后生物标志物.
- 建议进行进一步的前性研究,以证实这些发现并探索潜在的机制.
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