从1990年到2046年,非酒精性脂肪肝疾病的全球负担:使用GBD 2021数据进行基于全球人口的观察趋势分析
Guiming Chen1, Yanming Sha2, Ying Xiao3
1Interventional Medicine Department, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Medicine
|February 24, 2026
概括
由于人口增长和生活方式的变化,非酒精性脂肪性肝病 (NAFLD) 的发病率和负担在全球显著增加. 患病率和死亡率的差异正在扩大,特别是在中级SDI国家.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 全球卫生流行病学
- 公共卫生 公共卫生
背景情况:
- 非酒精性脂肪性肝病 (NAFLD),现在是与代谢功能障碍相关的脂肪性肝病,影响全球25%的人口.
- 肥胖和生活方式的改变是主要的驱动因素,给公共卫生和经济带来了巨大的负担.
- 在NAFLD的全球影响方面,日益扩大的健康差异是越来越令人担忧的.
研究的目的:
- 从1990年到2021年分析NAFLD的全球发病率,流行率,死亡率和DALYs.
- 调查地理模式,社会人口统计指数 (SDI) 相关性和时间趋势.
- 预测未来的NAFLD负担并分析健康不平等.
主要方法:
- 利用了2021年全球疾病负担研究的数据.
- 分析了SDI五分位数,地区和国家的趋势.
- 雇员年龄时期队列建模,分解和健康不平等分析,预测到2046年.
主要成果:
- 从1990年到2021年,全球NAFLD负担大幅增加,发病率上升1.95倍.
- 人口增长和流行病学转变是增加发病率的关键驱动因素.
- 在中等SDI国家和特定高负担地区,负担最高,差距越来越大.
结论:
- 纳氏肺炎是一种普遍存在的全球健康挑战,其负担显著且日益增加.
- 在NAFLD患病率,死亡率和DALY方面,地理和社会人口差异正在扩大.
- 有针对性的预防和干预策略至关重要,特别是对于中等SDI设置和高负担地区.
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