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代谢功能障碍相关的脂肪肝疾病中翻译后修改的进化模式:综合的图书统计分析
Dian Qiang Yang1, Shun Mei Huang2,3, Sui Sui Luo2,3
1Zhejiang Key Laboratory of Geriatrics and Geriatrics Institute of Zhejiang Province, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People's Republic of China.
翻译后修改 (PTMs) 是代谢功能障碍相关的脂肪肝病 (MAFLD) 发病的关键. 这种文献测量分析绘制了全球研究趋势的地图,确定了像ubiquitination和acetylation这样的新兴主题,以指导未来的MAFLD研究.
科学领域:
- 肝病学和分子生物学
- 生物化学和新陈代谢
背景情况:
- 代谢功能障碍相关的脂肪肝病 (MAFLD) 是一种普遍的慢性肝病,也是晚期肝病的重要危险因素.
- 翻译后修饰 (PTMs) 在调节脂质代谢,炎症和纤维化方面发挥着关键作用,从而影响MAFLD的发病.
研究的目的:
- 系统地分析研究趋势,并确定MAFLD中PTM领域的知识差距.
- 提供有关PTM和MAFLD的全球研究格局的数据驱动概述.
主要方法:
- 2005-2024年出版物的图书统计分析从科学网络核心集合中获取.
- 使用CiteSpace,VOSviewer,R中的Bibliometrix以及大型语言模型进行定量和定性分析.
- 识别出版成果,引用数量,关键机构,有影响力的作者和主要期刊.
主要成果:
- 总共分析了2401个出版物,显示了20.76%的年增长率.
- 中国在出版量方面处于领先地位,而美国的引用量最高.
- 新兴的研究主题包括"分子对接"",ubiquitination"",N6-methyladenosine"",乙化"",甲基化"和"代谢".
结论:
- 这项研究绘制了MAFLD中PTM的全球研究格局,突出了关键趋势和合作.
- 确定的新兴研究前沿,如特定的PTM及其在MAFLD病原体中的作用,为未来的研究提供了基础.
- 大型语言模型为MAFLD背后的复杂机制提供了洞察力,为先进的理解和潜在的治疗策略铺平了道路.
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