儿科患者的早期结直肠癌
Sarp Tunalı1, Kamil Erözkan1, Yiğit Türk1
1Department of General Surgery, Ege University Hospital, İzmir, Türkiye.
Turkish journal of surgery
|February 24, 2026
概括
儿科结直肠癌很少见,但正在增加. 这个案例突出了一个17岁的年轻人.
科学领域:
- 在瘤学瘤学.
- 儿科手术 儿科手术
- 胃肠病学 胃肠病学
背景情况:
- 早期结直肠癌 (CRC) 发病率正在增加,特别是在年轻人群中.
- 儿科患者的结肠直肠癌很少见,经常出现迟到的阻塞性症状.
- 这份病例报告的重点是一个17岁的女性,患有晚期儿科CRC.
研究的目的:
- 描述儿童结直肠癌罕见病例的临床表现和管理.
- 强调在持续性胃肠道症状的差异诊断中考虑儿科CRC的重要性.
- 突出基因咨询在治疗儿科CRC中的作用.
主要方法:
- 一个17岁的女性出现了阻塞性症状的病例报告.
- 诊断工作包括计算机断层扫描 (CT) 扫描.
- 手术干预:腹腔切除术与扩展的左半球切除术和米库利茨大肠切除术.
- 组织病理学分析和基因突变查 (BRAF,KRAS,NRAS,不匹配修复蛋白,ATM基因).
主要成果:
- 确定了一个4厘米的脏曲瘤,有阻塞的迹象,并怀疑转移性介质淋巴腺病变.
- 组织病理学证实了带有广泛淋巴结转移的粘膜腺癌 (17/42).
- 没有检测到常见的CRC突变 (BRAF,KRAS,NRAS);不匹配修复蛋白表达是完整的. 在ATM基因中发现了一种不确定的变异.
结论:
- 在患有持续性胃肠道问题的儿童中,应考虑患儿儿科结直肠癌,因为延迟可能导致疾病进展.
- 遗传咨询对于管理和理解潜在的遗传联系至关重要.
- 外科医生和瘤学家之间的多学科合作对于最佳的患者结果至关重要.
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