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乳腺的特征性伪血管瘤性流体过度增生 (PASH)
Rahul Koshy1, Pragya Virendrakumar Jain1, Julie M Jorns1
1Medical College of Wisconsin, Milwaukee, WI, USA.
Histopathology
|February 24, 2026
概括
乳房的伪血管瘤性流体增生症 (PASH) 具有脂肪亡和纤维囊变化的特征,这表明它是一种慢性,与激素相关的过程. 帕什似乎不会增加乳腺癌的风险,CD34阳性有助于诊断.
科学领域:
- 乳腺病理学 乳腺病理学
- 组织病理学 组织病理学
- 免疫组织化学 免疫组织化学
背景情况:
- 伪血管瘤性流体增生症 (PASH) 是一种良性乳腺病变.
- 了解其组织病理学和免疫组织化学 (IHC) 概况对于准确的诊断和风险评估至关重要.
研究的目的:
- 在一个大型当代群体中调查PASH的组织病理学和IHC概况.
- 确定激素受体表达与PASH特征之间的关联.
- 评估PASH患者随后发生乳腺缺血或乳腺癌的长期风险.
主要方法:
- 追溯审查193个良性乳腺活检与PASH从185名患者.
- 创建一个组织微阵列用于IHC分析.
- 评估IHC标记物包括CD34,BCL-2,SMA,desmin,TRPS-1,ERG,β-catenin,ER和PR. 这些标记物.
主要成果:
- 缺血性脂肪坏死 (93.8%) 和纤维囊变化 (88.1%) 是PASH的常见发现.
- 观察到一致的,扩散的,强大的CD34阳性 (100%).
- 雌激素受体 (ER) 和孕激素受体 (PR) 的阳性分别在29%和33.7%的病例中被发现.
- 随后的乳腺形或癌症发生在5.4%的患者中,随访时间中位数为6.2年.
结论:
- 在PASH中ER/PR表达的频率低于此前所认为的.
- 脂肪坏死和纤维囊变化的存在支持PASH的慢性,与激素相关的病因.
- CD34阳性是PASH的可靠诊断标记,使其与模仿者区别开来.
- 帕什似乎没有增加患乳腺癌的风险.
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