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对良性视周膜瘤的单片式立体射线手术:长期瘤控制和避免辐射诱导的视神经病变的策略,随访10年

Eun Jung Lee¹, Hyun-Tai Chung¹, Jin-Wook Kim¹

¹Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Journal of Korean medical science

|February 24, 2026

概括

对于周眼脑膜瘤 (POMs) 的单片式立体性放射外科手术 (SF-SRS) 的较低剂量导致瘤进展,原因是覆盖范围不足. 优化SF-SRS剂量和覆盖范围对于长期的瘤控制和预防视力丧失至关重要.

科学领域:

神经外科神经外科
辐射瘤学辐射瘤学
眼科医生眼科眼科

背景情况:

周眼神经瘤 (POM) 经常接受较低的单片段立体性放射性手术 (SF-SRS) 剂量,以减轻辐射诱导的视神经病变 (RION) 风险.
对POMs的SF-SRS后的瘤控制和RION的综合长期数据有限.
这项研究旨在利用十年的后续数据为POM建立安全有效的SF-SRS战略.

研究的目的:

为了评估单片断片立体性射线外科手术 (SF-SRS) 对周围视膜瘤 (POMs) 的长期疗效和安全性.
确定用于瘤控制和预防辐射诱导视神经病变 (RION) 的最佳剂量计参数.
开发实施SF-SRS在POM管理中的实际策略.

主要方法:

用SF-SRS治疗并随访超过十年的POM患者 (距离光学器件 (OA) <2毫米) 的回顾性分析.
检查瘤和OA剂量计因素之间的相关性,以及它们对瘤控制和RION的影响.
统计分析以确定影响结果的重要因素.

主要成果:

分析了30名患者,平均随访时间为152个月.
无进展的十年生存率为70%,延迟治疗失败发生在SRS后107个月的中位数.
瘤覆盖率 (切断值:81%) 与长期瘤控制有显著的关联 (P=0.004),并且在视力受损的患者中没有观察到RION.

结论:

在POMs的SF-SRS期间瘤覆盖率不足有助于显著的长期瘤进展和视力下降.
坚持最佳剂量处方和覆盖范围对于实现持续的瘤控制和预防RION至关重要.
为了在POM管理中安全有效的SF-SRS,需要对最佳剂量范围进行进一步的研究.

关键词:

负面影响负面影响玛刀的使用方法结果的结果.周眼性脑膜瘤 (Perioptic Meningioma) 是一种脑膜瘤.放射性外科手术放射性外科

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