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Updated: Feb 25, 2026

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
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人类脱酶中活性位点与远位突变的结构和催化后果:从分子动力学模拟的见解

Soumyajit Karmakar1, Biman Giri1, Sabyashachi Mishra1

  • 1Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India. mishra@chem.iitkgp.ac.in.

Physical chemistry chemical physics : PCCP
|February 24, 2026
PubMed
概括

人类铁二氧化酶 (hIYD) 的突变通过破坏甲状腺激素合成,导致先天性甲状腺功能低下症. 计算分析揭示了特定的hIYD突变如何导致结构和能量缺陷,影响酶功能和疾病发病.

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