在过敏性喘的气道改造中,IFITM1对于上皮介质转换是必需的
Manni Zhu1,2, Xiaoqin Weng2,3, Chuanli Zhang2
1Department of Respiratory and Critical Care Medicine, Nantong First People's Hospital, Nantong, China.
The World Allergy Organization journal
|February 24, 2026
概括
干扰素诱导的跨膜蛋白1 (IFITM1) 在喘中升高,通过表皮-介质细胞过渡 (EMT) 促进呼吸道重塑. 向IFITM1可能为过敏性喘提供新的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 呼吸系统医学 呼吸系统医学
- 细胞生物学 细胞生物学
背景情况:
- 已知干扰素诱导的跨膜蛋白1 (IFITM1) 能够限制病毒感染.
- IFITM蛋白在与过敏性喘相关的T助手2 (Th2) 细胞分化中发挥作用.
- 表皮-介质细胞过渡 (EMT) 是过敏气道重塑的一个关键过程.
研究的目的:
- 为了研究IFITM1在EMT中的功能作用,在过敏性喘中.
- 阐明IFITM1参与喘相关EMT的潜在分子机制.
主要方法:
- 在人类喘组织和室内灰尘虫 (HDM) 诱导的小鼠模型中量化IFITM1表达.
- 使用具有IFNAR阻塞或IFITm1敲击的体外和体内模型来研究EMT机制.
- 评估的信号通路包括IFN-β和STAT1.1.
主要成果:
- 呼吸道IFITM1表达在喘患者和暴露于HDM的小鼠中显著增加.
- IFITM1上调是通过IFN-β和STAT1激活进行的.
- 抑制IFNAR或Ifitm1降低了HDM诱导的EMT和气道重塑.
- 暴露于HDM增加了IFITM1和TNC,促进了Th17细胞的分化和IL-17A的产生.
结论:
- 通过IFN-β/STAT1信号传递,IFITM1在气道上皮细胞中得到上调.
- IFITM1在过敏气道改造中对EMT做出了贡献.
- IFITM1代表了过敏性喘的潜在治疗标.
相关概念视频
Asthma-II: Pathophysiology and Classification
4.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.6K
Cell-matrix's Response to Mechanical Forces
3.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...
Anchoring junctions mechanically attach a cell to the...
3.7K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
2.0K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.0K
Asthma-I: Introduction
3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K
Asthma: Pathogenesis and Management
1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.5K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.5K


