从优先考虑到实施:通过第二轮优先考虑更新PARC WP5项目组合
Celia Garcia Arenas1, Kiara Aiello Holden1, Terje Svingen2
1Department of Pesticides Safety, German Federal Institute for Risk Assessment, Berlin, Germany.
Frontiers in toxicology
|February 24, 2026
概括
化学品风险评估伙伴关系 (PARC) 通过整合新方法来推进化学品风险评估. 更新的项目解决了毒性测试中的监管缺口,促进了新方法方法 (NAM) 的使用.
科学领域:
- 化学风险评估 化学风险评估 化学风险评估
- 毒理学 毒理学 毒理学
- 监管科学是一种监管科学.
背景情况:
- 化学品风险评估伙伴关系 (PARC) 旨在实施下一代风险评估 (NGRA).
- 监管机构面临着将创新方法纳入化学安全评估中的挑战.
- 欧盟化学品可持续发展战略指导了PARC的目标.
研究的目的:
- 概述PARC中更新的第5个工作包 (WP5) 危险评估项目组合.
- 为了说明从方法优先设定到PARC项目实施的进展.
- 突出新PARC项目如何解决监管差距,并支持新方法方法 (NAM) 的整合.
主要方法:
- 在董事会的意见下,进行了第二轮的方法优先级确定.
- 考虑欧洲化学品局的监管挑战的关键领域 (2023年).
- 根据优先级和监管需求更新WP5危险评估项目组合.
主要成果:
- 在WP5危害评估组合中增加了四个新项目.
- 项目重点关注发育和生殖性毒性,发育性免疫毒性和性二态性肝毒性.
- 一个横向项目旨在加速NAMs的监管采用.
结论:
- 更新的PARC WP5项目组合直接解决了发现的监管缺口.
- 新项目加强了PARC的实施阶段,使研究与监管需求保持一致.
- 帕克的更新战略有助于将NAM纳入化学风险评估,支持可持续发展目标.
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