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暴露于极端温度会在健康小鼠中诱导肺肠失调

Abubakar Zakari^1,2, Syue-Wei Peng³, Chia-Li Han⁴

¹International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Current research in microbial sciences

|February 24, 2026

概括

极端温度会扰乱小鼠的肺肠微生物群和相关途径. 这项研究揭示了热和冷暴露如何影响微生物群落,炎症和宿主健康,突出了气候变化带来的风险.

科学领域:

环境健康环境健康
微生物学微生物学
免疫学免疫学免疫学

背景情况:

气候变化与呼吸系统问题有关,但极端温度对肺肠轴的影响尚不清楚.
了解这些影响对于公共卫生至关重要,特别是对弱势群体至关重要.

研究的目的:

研究极端温度对小鼠肺肠微生物群及其生物通路的影响.
为了识别不同温度暴露引起的特定微生物和分子变化.

主要方法:

鼠被暴露在正常,低,高或波动的温度下.
通过16S rDNA测序分析的肺和肠道微生物群.
测量了短链脂肪酸 (SCFA),肠道炎症标志物 (LDH,IL-6,KC) 和血清代谢物. 进行了蛋白质基因分析.

主要成果:

在温度组中观察到肺部和肠道微生物多样性的显著变化 (β多样性).
特定的细菌类 (Deferribacterota,Desulfobacterota,Firmicutes,Verrucomicrobiota) 在肺部和便中表现出明显的变化.
极端温度诱导了肠道炎症,改变了血清SCFA,并揭示了与代谢,免疫力和细胞压力相关的温度依赖的蛋白质基因表达模式.

结论:

暴露于极端温度会导致小鼠的肺肠失调,肠道炎症和代谢失衡.
这些干扰会影响宿主微生物群的稳态,可能增加对不良健康结果的敏感性.
这些发现强调了气候变化导致的极端温度事件所带来的健康风险.

关键词:

气候变化气候变化气候变化极端的温度极端的温度.炎症炎症是一种炎症.微生物组是一个微生物组.蛋白质组学是指蛋白质组学.

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