伴随性失眠和阻塞性睡眠呼吸暂停会增加心血管和脑血管疾病的风险
Yen-Ting Lu1,2,3,4, Hsueh-Yu Li5,6, Yu-Ru Lin3
1Department of Otolaryngology-Head and Neck Surgery, St. Martin De Porres Hospital, Chiayi, Taiwan.
Sleep
|February 24, 2026
概括
与仅有阻塞性睡眠呼吸暂停 (OSA) 患者相比,患有并发性失眠和阻塞性睡眠呼吸暂停 (COMISA) 的患者面临大脑血管疾病和血栓事件的长期风险增加.
科学领域:
- 睡眠医学 睡眠医学
- 心血管科学 心血管科学
- 神经学 神经学
背景情况:
- 伴随性失眠和阻塞性睡眠呼吸暂停 (COMISA) 是一个公认的临床实体.
- COMISA可能会对心脑血管产生潜在影响.
- 了解与COMISA相关的长期风险至关重要.
研究的目的:
- 为了比较COMISA患者的心血管和脑血管疾病 (CCVD) 的长期风险与单独的阻塞性睡眠呼吸暂停 (OSA).
- 为了确定与COMISA相关的特定CCVD亚型.
- 将COMISA描述为一个独特的临床表型.
主要方法:
- 利用TrinetX美国协作网络进行成人OSA诊断 (2010-2023年).
- 定义COMISA为OSA,在90天内诊断出失眠;只有OSA作为对照.
- 员工 1:1 倾向性得分匹配和估计的 10 年 CCVD 风险和危险比率 (HR).
主要成果:
- 匹配的队列包括165,522名COMISA患者和165,522名单独患有OSA的患者.
- COMISA显示大脑血管疾病 (HR 1.17),心律失常,缺血性心脏病和血栓性疾病的10年风险更高.
- 对于主要的不良心血管事件 (HR 1.03) 观察到一个适度的关联.
结论:
- COMISA与特定心脑血管疾病的长期风险增加有关,特别是脑血管和血栓事件.
- 这些发现强调了COMISA作为高风险的临床表型.
- 对管理COMISA的进一步研究是有必要的.
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