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Updated: Jul 18, 2026

Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis
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在不调节TDP-43病理的情况下,CPEB3可以选择性地抑制α-synuclein聚合

Ann Teres Babu1, Mufeeda Farhana A1, Harsha Varthini Periasamy1

  • 1School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram (IISER TVM), Thiruvananthapuram, India.

FEBS letters
|February 24, 2026
PubMed
概括

CPEB3类域1 (PRD1) 选择性地抑制了α-synuclein (α-Syn) 粉样蛋白聚合,这是帕金森病的一个关键因素. 它不会影响TARDNA结合蛋白43 (TDP-43) 的聚合.

关键词:
核磁共振光谱法 (NMR) 是一种光谱法.帕金森病是帕金森病的一种.在TDP-43中.聚合抑制剂聚合抑制剂阶段分离的阶段分离.蛋白质蛋白质相互作用α-synuclein 是一种同核蛋白.

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