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Updated: Feb 25, 2026

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对 (脱氧) рибо的代谢同位素标记使得能够进行双中性损失扫描,以分析核酸修饰的概况

Shao-Qin Rong1,2,3,4,5, Zhi-Han Jin1,5, Dong-Rui Yin1,5

  • 1Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai 200032, China.

Nucleic acids research
|February 24, 2026
PubMed
概括

一种新的代谢标记方法使得DNA和RNA修饰的敏感检测成为可能. 这种技术准确量化罕见的核化物,并识别出新的添加物,改善了我们对核酸功能的理解.

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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