剖腹产产量和后代长期神经发育障碍的风险
Tak Kyu Oh1,2, In-Ae Song1,2
1Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
概括
剖腹产医院手术量较高与儿童长期神经发育障碍 (LNDD) 风险降低有关. 优化低音量设置对于保护儿童神经发育至关重要.
科学领域:
- 儿科健康 儿科健康
- 产科 产科 产科 产科 产科
- 神经科学是一个神经科学.
背景情况:
- 机构手术的数量会影响外科手术的结果.
- 剖腹产分娩医院体积对儿童神经发育的影响尚不清楚.
研究的目的:
- 研究医院剖腹产产量与后代长期神经发育障碍 (LNDD) 风险之间的关联.
- 为了确定更高的医院体积是否与更好的神经发育结果相关.
主要方法:
- 使用韩国国家医疗保险服务数据 (2010-2014年出生) 的回顾性全国性队列研究.
- 追踪到2023年的735280例剖腹产,将医院分类为年度体积四分之一.
- 使用多变量Cox比例危险模型来评估LNDD风险,调整共变量.
主要成果:
- 在12.4年内,4.2%的儿童被诊断出患有LNDD.
- 在较高体积四分位数 (Q2-Q4) 的医院,与最低四分位数 (Q1) 相比,LNDD的调整风险明显较低.
- 对于智力障碍和心理发展障碍,也观察到反向关联.
结论:
- 超过最低四分位数的医院剖腹产量独立地与后代LNDD风险的降低有关.
- 在更高的四分位数中观察到平原效应,而不是线性剂量反应.
- 在低人数环境中优化机构准备对于保护儿童神经发育至关重要.
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