过敏性鼻炎,乙酸性炎症和鼻聚中术后复发之间的关联
Wei Zhong1,2,3,4, Shaobing Xie1,2,3,4, Haijun He5,6
1Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, People's Republic of China.
过敏性鼻炎 (AR) 在患有鼻息肉的慢性鼻炎 (CRSwNP) 患者中显示出较高的组织异osinophilia,并增加了手术复发的风险. AR独立地预测了更早的复发和更短的无复发生存期.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 过敏性鼻炎 (AR) 经常与具有鼻息肉 (CRSwNP) 的慢性鼻炎同时发生.
- 对AR对CRSwNP组织内型和患者预后的具体影响尚不清楚.
- 了解这种关系对于改善治疗策略和患者结果至关重要.
研究的目的:
- 为了研究伴随性过敏性鼻炎 (AR) 对组织异性炎症和术后复发率在慢性鼻炎与鼻息肉 (CRSwNP) 的患者的影响.
- 确定AR是否是CRSwNP.功能性内镜外科手术 (FESS) 后复发的独立预测因素.
主要方法:
- 追溯队列研究涉及603名CRSwNP患者在第三级转诊中心接受FESS.
- 患者根据并发性AR的存在或不存在将患者分为不同的群体.
- 分析包括临床数据,外围和组织乙氨基水平,以及使用多变量Cox回归和Kaplan-Meier生存分析的术后复发率.
主要成果:
- 与非AR组相比,AR组 (n=202) 呈现出更高的先前手术,喘和增加的组织乙氨基酸细胞数量和百分比.
- 经历了复发的患者出现了更高的AR患病率,高色素水平,更多的先前手术和更高的隆德-麦凯分数.
- 鉴定出AR是术后复发的独立预测因子,与较早的复发和较短的无复发存活期有关.
结论:
- 合并性过敏性鼻炎 (AR) 确定了CRSwNP患者的一个独特的亚组,其特点是显著的组织异osinophilia.
- 在CRSwNP患者中,AR是增加风险和早期出现术后复发的独立预测因素.
- 这些发现表明AR放大了局部乙酸性炎症,导致CRSwNP的FESS后预后较差.
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