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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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微孔封闭的ROS响应的3D打印芯支架用于长期的NO释放,用于编排糖尿病骨缺陷修复中的免疫调节和血管生成.

Jiali Guo1,2, Weihang Guo1, Haoming Lin1

  • 1Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Department of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.

Advanced materials (Deerfield Beach, Fla.)
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概括

一种新型的支架可持续3个月提供氧化 (NO),通过中和活性氧物种 (ROS) 并促进血管-骨质合,增强糖尿病骨缺陷愈合.

关键词:
3D打印的脚手架是使用3D打印的.骨血管化的重建.糖尿病患者的骨缺陷修复微孔的外 - 核心结构结构.持续的 NO 释放.

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科学领域:

  • 生物材料科学 生物材料科学
  • 再生医学是一种再生医学.
  • 组织工程是组织工程.

背景情况:

  • 糖尿病患者的骨缺陷愈合受到炎症,氧化应激和不良血管化的阻碍.
  • 氧化 (NO) 具有治疗潜力,但其半衰期短,释放不受控制.
  • 现有的输送系统无法为慢性糖尿病患者的骨修复提供持续的NO.

研究的目的:

  • 开发一个微孔受限,持续的氧化 (NO) 输送系统,用于糖尿病患者的骨再生.
  • 设计一个精确控制L-氨酸 (L-Arg) 释放的支架,以便按需生成NO.
  • 研究持续NO释放对调节糖尿病骨微环境的治疗作用.

主要方法:

  • 使用相分离制造3D打印的脚手架,采用可降解ROS的水凝核心 (L-Arg) 和nHA/PCL外.
  • 微孔封闭策略,以控制L-Arg释放和现场NO产生.
  • 在体外和体内研究评估脚手架的性能,NO释放动力学和骨再生功效.

主要成果:

  • 脚手架提供了持续的NO释放3个月,避免爆裂毒性.
  • 微孔封闭使得可控的L-Arg释放和局部的ROS/L-Arg反应产生NO.
  • 该系统有效中和了ROS,促进了M2巨细胞的两极分化,增强了血管生成,并在体外和体内刺激了骨质分化.

结论:

  • 微孔封闭的支架提供了一个多功能平台,用于在复杂的病理条件下持续,按需的NO输送.
  • 这种方法通过调节炎症,氧化应激和血管-骨质原生合来协同增强糖尿病骨再生.
  • 开发的系统代表了治疗慢性糖尿病骨缺陷的有希望的策略.