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Updated: Feb 26, 2026

Capillary Electrophoresis-based Hydrogen/Deuterium Exchange for Conformational Characterization of Proteins with Top-down Mass Spectrometry
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使用紫外线光解离质谱法对蛋白质离子进行自上而下的表征

Hanlin Ren1, Jennifer S Brodbelt1

  • 1Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.

Journal of the American Society for Mass Spectrometry
|February 24, 2026
PubMed
概括

紫外线光解离 (UVPD) 通过有效地分裂蛋白质离子来推进负模式的自上而下的蛋白质组学. 这种方法提高了酸性蛋白质组分析的序列覆盖率,克服了以前的局限性.

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