微塑料和纳米塑料对脏的影响
Lucie Augey1, Jessica Berdougo-Tritz1, Aicha Mbarek1
1GPR, Paris, France.
概括
微塑料和纳米塑料 (MNP) 通过引起炎症和损伤,可能会损害脏健康. 需要进一步的研究来了解塑料的毒性及其对病患者的影响.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 塑料是持久性疏水性碳聚合物,具有较长的环境半衰期.
- 广泛的塑料生产和积累引发了严重的毒性问题.
- 人类接触微塑料和纳米塑料 (MNPs) 是常规的,有潜在的器官积累,包括脏.
研究的目的:
- 审查现有关于塑料毒性影响的研究.
- 探索MNP诱导的毒性的潜在机制.
- 检查慢性病 (CKD) 和透析对MNP暴露和脆弱性的影响.
主要方法:
- 综述了多项研究,调查MNP对哺乳动物脏和人类脏细胞的影响.
- 分析证据,将MNP暴露与氧化应激,炎症和细胞毒性联系起来.
- 检查病学变化和功能生物标志物的改变.
主要成果:
- 有证据表明,MNP诱导毒性,其特征是氧化应激和炎症反应.
- 暴露于MNP会导致组织病理学变化 (球状细胞/管状细胞损伤,纤维化) 和脏生物标志物 (GFR,白蛋白尿,BUN) 的改变.
- MNPs可能会导致心血管损伤和CKD进展,可能是通过基碳化合物受体激活.
结论:
- 许多MNP对脏健康构成威胁,诱导细胞毒性和脏损伤.
- 毒性因与其他污染物同时暴露而加剧,并受CKD状态的影响.
- 透析患者面临更高的MNP暴露,增加他们的脆弱性;进一步的研究是至关重要的.
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