CT校准曲线对使用诊断CT扫描和计划CT支持DirectDensity重建的放射治疗计划的影响
Fabian Krause1, Frank-André Siebert1
1Department of Radiotherapy, University Medical Center Schleswig-Holstein, Kiel, Germany.
Journal of applied clinical medical physics
|February 24, 2026
概括
在紧急放射治疗工作流程中使用DirectDensity校准曲线与诊断CT数据是临床上可接受的. 混合曲线显示出最好的准确性,确保剂量偏差保持在患者治疗的可接受范围内.
科学领域:
- 医学物理 医学物理
- 辐射疗法 辐射疗法
- 图像指导疗法是指导图像的疗法.
背景情况:
- DirectDensity提供管电压独立的密度校准CT图像,用于放射治疗治疗计划.
- 诊断CT (dCT) 数据通常在没有DirectDensity校准的紧急工作流中使用.
- 不同CT校准曲线对紧急放射治疗中剂量准确性的影响尚未得到充分证实.
研究的目的:
- 研究各种CT校准曲线对人工智能支持的紧急放射治疗工作流程中的治疗计划的影响.
- 通过基于幻影的端到端测试和回顾性患者数据分析来评估剂量偏差.
- 为了验证幻影测量的可转移性到临床紧急放射治疗场景.
主要方法:
- 在使用Alderson-Rando幻影的Varian Ethos平台上模拟了一个适应性放射治疗工作流.
- 采用了三个校准曲线:DirectDensity,120kV和一个定制的混合曲线.
- 通过电离室测量进行端到端测试,并在回顾性患者计划上进行马分析.
主要成果:
- 所有测试的校准曲线都符合ICRU报告24的要求 (±5%的剂量偏差).
- 混合曲线的准确性略有提高 (0.1%-0.7%),并且始终表现最好.
- 校准曲线之间的剂量差异处于临床上可接受的范围内 (与校准规划CT相比,<1.5%的偏差).
结论:
- 对于使用dCT数据的紧急工作流程,DirectDensity校准曲线在临床上是可以接受的.
- 自生成的混合CT密度曲线产生了最佳的剂量准确性.
- 校准曲线的选择会影响剂量分布,这强调了优化这一参数在紧急放射治疗中的临床相关性.
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