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结合性肺纤维化和肺瘤中纤维化的放射性模式:对疾病轨迹和预后结果的影响
Min Seon Kim1, Jooae Choe2, Hye Jeon Hwang2
1Department of Radiology, Seoul National University Bundang Hospital, Seoul, Korea.
在结合性肺纤维化和肺气 (CPFE) 患者中,纤维化模式会影响进展率,但不会影响存活率. 基线纤维化程度和肺癌等不良事件是关键的生存决定因素.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 电脑图像扫描 (CT) 影像成像
背景情况:
- 结合性肺纤维化和肺气 (CPFE) 呈现出不同的放射学模式.
- 这些模式对疾病进展和患者结局的影响尚不清楚.
研究的目的:
- 调查CPFE中不同放射性纤维化模式如何影响疾病轨迹.
- 确定CPFE患者纤维化模式和临床结果之间的关联.
主要方法:
- 对236名CPFE患者 (2011-2021) 的高分辨率CT扫描进行了回顾性分析.
- 纤维化模式被分类为通常的间歇性肺炎 (UIP),非特异性间歇性肺炎 (NSIP),与吸烟有关的间歇性纤维化 (SRIF) 或脱皮间歇性肺炎 (DIP).
- 深度学习用于肺和纤维化量化;考克斯模型分析了纵向结果.
主要成果:
- 纤维化进展率因模式而异:UIP (1.2年) 最快,NSIP (2.1年) 中间,SRIF/DIP (3.0年) 最慢.
- 纤维化模式与肺的进展,存活率,肺癌或急性恶化之间没有发现显著的关联.
- 增加基线纤维化程度,肺癌和急性恶化与较差的生存率有关.
结论:
- 在CPFE中,纤维化模式与纤维化进展的速度相关.
- 患者的生存率主要受到初始纤维化程度和临床事件 (如肺癌和急性恶化) 的影响.
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