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乳房切除术后的慢性疼痛:当前的知识和知识差距

Savera Khan1, Abby P Chiu1, Cathryn Payne2

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乳房切除术后疼痛综合征 (PMPS) 影响高达52%的患者,影响生活质量. 本综述综合了关于PMPS预防和治疗的当前知识,并确定了未来研究的关键风险因素和知识差距.

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科学领域:

  • 在瘤学瘤学.
  • 疼痛医学 医学 疼痛医学
  • 手术并发症 手术并发症

背景情况:

  • 乳腺切除术后疼痛综合征 (PMPS) 是乳腺癌手术后常见且令人衰弱的并发症.
  • 它通常呈现为持续的神经病痛,显著降低患者的生活质量和功能.

研究的目的:

  • 审查和综合有关PMPS流行病学,预防和治疗的当前知识.
  • 识别知识缺口,并为管理PMPS的未来研究方向提供信息.

主要方法:

  • 对PMPS现有的文献进行系统审查.
  • 对流行病学数据,风险因素,预防策略和治疗选择的分析.

主要成果:

  • PMPS的发病率在28-52%之间,与年轻的年龄,广泛的手术和先前存在的疼痛有关.
  • 有前途的预防策略包括EMLA奶油,普雷加巴林和PECS II阻断剂.
  • 有效的治疗方法可能包括局部素,阿米特里普提林,文拉法辛和基于正念的认知疗法.

结论:

  • 对于PMPS干预的证据受到研究异质性和小样本大小的限制.
  • 进一步研究分子机制和大规模临床试验对于有效管理至关重要.
  • 识别个性化医疗方法的生物标志物对于未来的PMPS治疗至关重要.